Print this page Email this page
Users Online: 458
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Contacts Login 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 27  |  Issue : 2  |  Page : 140-143

Nitrous oxide for the prevention of rocuronium injection pain: A randomized, double-blind, controlled clinical trial


Department of Anesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Deban L Singh
Department of Anesthesiology, Regional Institute of Medical Sciences, Imphal - 795 004, Manipur
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4958.121593

Rights and Permissions

Background: Pain on injection of rocuronium bromide is a common side-effect in anesthetic practice. This study has been carried out to assess the effect of nitrous oxide on the pain and withdrawal response caused by rocuronium injection. Materials and Methods: A prospective, randomized, double-blind, placebo-controlled study was carried out in the department of Anesthesiology, Regional Institute of Medical Sciences, Imphal to determine the effect of nitrous oxide (N 2 O) on the frequency and severity of pain and withdrawal reactions after injection of rocuronium. 80 (Eighty) ASA physical status I and II patients undergoing general anesthesia for elective surgery were enrolled. The patients were divided into group O and group N and randomized to receive 100% oxygen (O 2 ) or 50% N 2 O in O 2 for 2 minutes followed by a sub-paralyzing dose of rocuronium 0.06 mg/kg. After induction of anesthesia with thiopentone 5 mg/kg, an intubating dose of rocuronium 0.6 mg/kg was given. The patients were observed after injection of rocuronium 0.06 mg/kg, and asked to rate pain in the arm on a 4-point (0-3) verbal rating scale (none, mild, moderate or severe). After the intubating dose of rocuronium, withdrawal reactions were recorded. Results: Thirty-five patients (87.5%) in the group N and 20 patients (50%) in the group O reported no pain (P <0.001). The pain was mild in 5 (12.5%) and 20 (50%) patients in nitrous group and oxygen group, respectively, (P < 0.001). Withdrawal response after an intubating dose of rocuronium was observed in 4 (10%) and 11 (27.5%) patients in the N 2 O and O 2 groups, respectively, (P <0.05). No patients reported moderate or severe pain. Conclusion: Inhalation of 50% N 2 O in O 2 reduces the incidence and severity of pain and the withdrawal reactions associated with rocuronium injection.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1723    
    Printed43    
    Emailed0    
    PDF Downloaded197    
    Comments [Add]    

Recommend this journal