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ORIGINAL ARTICLE
Year : 2018  |  Volume : 32  |  Issue : 1  |  Page : 33-39

Investigation of risk factors associated with malaria and yellow fever coinfection among febrile patients in Ilorin, Nigeria


Infectious Diseases and Environmental Health Research Group, Department of Microbiology, Faculty of Life Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria

Correspondence Address:
Dr. Olatunji Matthew Kolawole
Infectious Diseases and Environmental Health Research Group, Department of Microbiology, Faculty of Life Sciences, University of Ilorin, P.M.B. 1515, Ilorin
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4958.213955

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Context: Yellow fever (YF) is an infection which could lead to hemorrhage, and malaria is a highly prevalent infectious disease in Africa. These diseases have accounted for colossal loss of lives over time. Aim: To investigate the likelihood of concurrent malaria and YF infection as well as yellow fever virus (YFV) IgG serostatus with respect to predisposing risk factors. Settings and Design: A cross-sectional study of febrile patients attending hospitals in Ilorin metropolis in the first quarter of 2016. Materials and Methods: Blood samples were collected from 176 participants, and the malaria status was determined using rapid diagnostic tests. Positive malaria samples were subjected to reverse transcriptase-quantitative polymerase chain reaction to assay for YFV to ascertain coinfection with YF. All the samples were also tested for anti-YFV IgG antibodies using ELISA. Statistical Analysis Used: Data were analyzed using Statistical Package for the Social Sciences software and Excel. Results: Only 13 (7.4%) participants were positive for malaria and no case of malaria and YF coinfection. There was no statistical association (P > 0.05) between the acquisition of malaria and the predisposing risk factors examined. An overall seroprevalence of anti-YFV IgG antibodies of 21.6% was found. Among the risk factors assessed, age group and marital status had a statistical association with anti-YFV IgG antibodies serostatus of the participants (P < 0.05). Thirty (17%) participants reported that they had been vaccinated against YFV, and 21 (70%) of the vaccinees were seronegative for anti-YFV IgG antibodies. Conclusions: This study revealed a low prevalence of malaria and anti-YFV IgG antibodies, as well as low YF vaccination coverage in Ilorin metropolis.


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