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Year : 2013  |  Volume : 27  |  Issue : 1  |  Page : 31-35

Serum homocysteine in type 2 diabetes with cardiovascular complications

1 Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, Manipur, India
2 Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Maisnam Amuba Singh
Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, Manipur - 795 004
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.116631

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Objectives: To determine the association between plasma homocysteine concentration and metabolic parameters in type 2 diabetes mellitus with and without cardiovascular complications. Materials and Methods: Cases of sixty type 2 diabetes mellitus patient (thirty with cardiovascular complications and another thirty without cardiovascular complications) were randomly selected from patients attending Diabetes Clinic and Medical wards, RIMS, Imphal. Another thirty age and sex-matched normal volunteers were taken as control. Serum homocysteine was estimated by ELISA. F-test (ANOVA) and correlation technique were used to analyze the data sets. Results: The serum homocysteine levels of type 2 diabetes mellitus patients both with and without cardiovascular complications were found to be significantly higher (P < 0.001) than the control subjects with 27.20 ± 6.02 μmol/l and 18.03 ± 4.61 μmol/l compared to 9.36 ± 1.70 μmol/l in the controls. Homocysteine is positively correlated with total cholesterol (r = 0.121, P < 0.05) and negatively correlated with HDL level (r= −0.166, P < 0.05). A positive correlation is found between the serum homocysteine level and blood pressure. Conclusions: Homocysteine and dyslipidaemia increases the cardiovascular risk significantly in type 2 diabetes mellitus. Homocysteine may be estimated as a prognostic indicator to assess the risk of developing cardiovascular complications.

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