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CASE REPORT
Year : 2013  |  Volume : 27  |  Issue : 1  |  Page : 80-81

Linear IgA bullous dermatosis


Department of Dermatology, Venereology and Leprology, RIMS, Imphal, Manipur, India

Correspondence Address:
Nandakishore Thokchom
Department of Dermatology, Venereology and Leprology, RIMS, Imphal, Manipur
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4958.116656

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Linear IgA disease is a rare chronic autoimmune subepidermal blistering disorder characterized by the linear deposition of IgA along the dermoepidermal junction. A 40-year-old housewife presented with symmetrically distributed generalized intensely pruritic vesiculobullous lesions of 1 year duration. Previous treatment with oral and topical steroids had induced only a temporary remission of the skin lesions. There was no history of drug intake in the recent past and her medical history was insignificant and there was no similar illness in her family members. Examination findings included vesicles arranged at the periphery of healed lesions along with post-inflammatory hyperpigmented macules on the trunk and extremities. There was no genital, mucosal or ocular involvement. Skin biopsy from the leg showed dense neutrophilic infiltration along with eosinophils at the tip of the dermal papillae and focal areas showed dermoepidermal clefting with bulla formation. Direct immunofluorescence of perilesional skin revealed linear deposits of IgA at the basement membrane zone. Therapeutically the patient responded well to dapsone. Though the presentation was classical, the case is reported for its rarity.


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