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Year : 2013  |  Volume : 27  |  Issue : 3  |  Page : 165-168

Cimetidine-induced Hyperprolactinemia

Department of Pharmacology, J. N. Institute of Medical Sciences, Porompat, Imphal, Manipur, India

Correspondence Address:
Oinam Joychandra Singh
Department of Pharmacology, J. N. Institute of Medical Sciences, Porompat, Imphal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.127383

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Pharmacologic hyperprolactinemia is a problem of underestimated prevalence. This is due to lack of externally visible symptoms, patients' reluctance for embarrassing disturbs, and/or clinicians' lack of awareness. The secretion of prolactin is mainly controlled by hypothalamus over lactotrophs of anterior pituitary through D2 receptor along with many inhibitory and excitatory transmitters particularly serotonin, histamine, and estrogen. Here, the role of histamine receptors (H1 and H2) and their antagonists in the change of serum prolactin level with special reference to the mechanism of action of cimetidine is discussed. It may also conclude with the modifying role of histamine in inducing prolactin secretion through dopamine- GABA-serotoninergic system or modifying PRFs or other unknown mechanism. Therefore, proper evaluation of the hyperprolactinemia, particularly in infertile women, is recommended before extensive diagnosis and therapeutic procedures as hyperprolactinemia may be associated with normal pituitary function. Based on this basic idea, the role of histamine receptor (H 1 and H 2) and cimetidine is discussed. It is concluded that cimetidine may be acting on modifying the role of histamine-induced prolactin secretion, which in term is through dopamine GABA-serotoninergic system/modifying PRFs/other unknown mechanism.

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