| ORIGINAL ARTICLE |
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| Year : 2014 | Volume
: 28
| Issue : 1 | Page : 18-21 |
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The effect of pregabalin for relief of postoperative pain after abdominal hysterectomy
Tashi Chotton, Nongthombam Ratan Singh, Langpolakpam Chaoba Singh, Pradipkumar Singh Laithangbam, Haorongbam Shanti Singh
Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, India
Correspondence Address:
Dr. Pradipkumar Singh Laithangbam
Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-4958.135219
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Background: Failure to provide postoperative pain relief is morally and ethically unacceptable. Combination of nonopioid analgesics is being increasingly used to reduce opioid-related side effects. Pregabalin, having an inhibitory modulation of neuronal excitability, is being evaluated in this randomized controlled trial. Materials and Methods: Following institutional ethical clearance, 90 adult females (aged 18-60 years, ASA I and II) undergoing elective abdominal hysterectomy were randomized into two groups (n = 45). Group A patients received pregabalin 150 mg and Group B patients received placebo (vitamin C), 1 h prior to induction of anesthesia. Intraoperative analgesia was provided with paracetamol infusion 1,000 mg over 15 min. Postoperative pain (visual analog scale/VAS), postoperative nausea and vomiting ( four point ordinal scale ) and sedation scale ( Ramsay ) were monitored at 0, 0-4, 4-12, and 12-24 h time intervals. Results: Both static (at rest) and dynamic (during coughing) pain score (VAS) and the consumption of rescue analgesia (ketorolac) were significantly (<0.001) less in the pregabalin group. There were no significant differences in the postoperative nausea and vomiting, and Ramsay sedation scale. Conclusion: Preoperative pregabalin had significant effect in relieving postoperative pain when given as an adjuvant. |
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