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Year : 2014  |  Volume : 28  |  Issue : 1  |  Page : 47-48

Epidermolytic hyperkeratosis in verrucous epidermal nevus

Department of Dermatology, Venereology and Leprology, RIMS, Imphal, Manipur, India

Correspondence Address:
Dr. Dilimpou Pamei
Department of Dermatology, Venereology and Leprology, RIMS, Imphal, Manipur
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.135235

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Epidermal nevi are hamartomas that are characterized by hyperplasia of the epidermis and adnexal structures. Most cases arise sporadically during development of the embryo, but familial patterns of inheritance have been observed. Only 5-10% of patients with verrucous epidermal nevus show histological features of epidermolytic hyperkeratosis. This has a significant clinical importance as this patient carry the risk of parenting a child of congenital bullous ichthyosiform erythroderma. A 7-year-old boy born of non-consanguineous marriage presented with non-pruritic multiple verrucous papules that coalesce to form well-demarcated, skin colored to brown, papillomatous plaques over the right side of abdomen, right loin, right legs including a cauliflower like verrucous plaque over the umbilicus distributed along the line of Blaschko noticed since 1-year of age. Oral cavity, palms and soles were spared. Developmental milestones were normal. A diagnosis of verrucous epidermal nevus was made. Histology showed hyperkeratosis, papillomatosis and vacuolization of the cells in the stratum spinosum and granulosum with keratohyalin granules. Routine examination of blood and chest X-ray were normal. This case is being reported to highlight the rare histological features and to re-emphasize the importance of routine histological examination and genetic counseling in all cases of verrucous epidermal nevus.

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