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ORIGINAL ARTICLE
Year : 2014  |  Volume : 28  |  Issue : 2  |  Page : 94-98

A comparative study of clonidine and gabapentin for attenuating hemodynamic responses to laryngoscopy and tracheal intubation


Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Dr. Nongthombam Ratan Singh
Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal - 795 004, Manipur
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4958.141090

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Background: Laryngoscopy and intubation causes reflex sympatho-adrenal response in the form of tachycardia and hypertension. The present study compared oral gabapentin with oral clonidine for attenuating hemodynamic responses to laryngoscopy and tracheal intubation. Materials and Methods: Ninety patients of American society of Anesthesiologists (ASA) I and II in the age-group of 18-60 years, of either sex, posted for elective surgeries under general anesthesia were randomly divided into three groups (n = 30). On the morning of surgery, the study medications were given orally with sips of water 2 hour pre-operatively as: Group I received 200 μg clonidine, Group II received 900 mg gabapentin, and Group III received placebo. The heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were observed and recorded as 0 minute (baseline) and at 1, 3, 5, and 10 minutes after endotracheal intubation. Results: Oral clonidine (200 mcg) attenuated the increase in systolic blood pressure, diastolic blood pressure, and mean arterial pressure better than oral gabapentin (900mg). The increase in heart rate was significantly attenuated by clonidine as compared to gabapentin and placebo (P < 0.001). Gabapentin also attenuated tachycardiac response but it was not completely eliminated. As compared with placebo, gabapentin attenuated rise in diastolic blood pressure and mean arterial pressure at 3 and 5 minutes after intubation (P < 0.38, 0.007 at 3 and 5 minutes. Conclusion: Both clonidine and gabapentin attenuate hemodynamic response to laryngoscopy and tracheal intubation. Clonidine is a better drug compared to gabapentin and tachycardiac response was significantly attenuated.


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