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Year : 2016  |  Volume : 30  |  Issue : 2  |  Page : 79-83

The acute effect of erythropoietin on mean corpuscular hemoglobin concentration levels during hypoxia - reoxygenation injury in rats

1 Department of Obstetrics and Gynecology, Mesologi County Hospital, Etoloakarnania, Greece
2 Department of Obstetrics and Gynecology, Aretaieion Hospital, Attiki, Greece
3 Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
4 Exprerimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki, Greece

Correspondence Address:
Constantinos Tsompos
Department of Obstetrics and Gynecology, Mesologi County Hospital, Nafpaktou Street, Mesologi - 30200, Etoloakarnania
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.182905

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Background: The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an hypoxia reoxygenation (HR) protocol. The effect of that molecule was studied hematologically using mean corpuscular hemoglobin concentration (MCHC) levels. Materials and Methods: 40 rats of mean weight 247.7 g were used in the study. MCHC levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reoxygenation. Erythropoietin (Epo) was administered only in groups C and D. Results: Epo administration significantly increased the MCHC levels by 1.73% +0.50% (P = 0.006). Reoxygenation time non-significantly increased the MCHC levels by 0.17%+0.56% (P = 0.7555). However, erythropoietin administration and reoxygenation time together produced a significant combined effect in increasing the MCHC levels by 0.89% +0.31% (P = 0.0061). Conclusion: Erythropoietin administration whether it interacted or not with reoxygenation time has significant increasing short - term effects on recovery pathophysiology of MCHC levels.

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