Print this page Email this page
Users Online: 442
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Contacts Login 
Year : 2016  |  Volume : 30  |  Issue : 3  |  Page : 135-140

Effects of oral prednisolone and fluticasone nasal spray in the management of nasal polypi

1 ENT Specialist, Government of Nagaland, Nagaland, India
2 Assistant Professor of ENT, SMIMS, Gangtok, Sikkim, India
3 ENT Specialist, Government of Mizoram, Mizoram, India
4 ENT Specialist, Government of Manipur, Imphal Manipur, India
5 Professor and Head of ENT, JNIMS, Imphal Manipur, India

Correspondence Address:
Mohonish N Chettri
Assistant Professor of ENT, SMIMS, Gangtok, Sikkim
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-4958.191176

Rights and Permissions

Background : Nasalpolyp presents a significant challenge in management due to its frequent recurrences. This study focuses on a medical model of combined local and systemic therapy for efficacy. Aims: Evaluation of a combined therapy, oral prednisolone, and fluticasone propionate nasal spray in the management of nasal polypi. Materials and Methods: This study was carried out in a tertiary care hospital in northeast India during a period of 18 months from 2010 to 2011. The recruitment of patients was done for 13 months and follow-up done for 3 months. The diagnosis made on the basis of physical examination, diagnostic nasal endoscopy, and radiological findings. The patients were evaluated for effects of combined treatment with fluticasone propionate nasal spray and oral prednisolone and followed up for 3 months. Descriptive statistics and analysis were carried out wherever applicable and P < 0.05 was considered statistically significant. Results: Altogether 67 patients were enrolled in this study. The most common presentation was observed in males in the fourth decade. With our modality, 98.5% showed a reduction in nasal obstruction score after treatment, and 83.6% showed a reduction in nasal discharge symptom score. Sixty patients (89.6%) showed a reduction in hyposmia symptom score after treatment and 68.7% showed a reduction in facial pain symptom score after treatment. Nasal polyp size was found to be significantly reduced after treatment, and no patients developed any adverse effects during or following the treatment initiation except mild burning sensation with fluticasone nasal spray (three patients) which subsided after a few days. Conclusion: We found that a 3-week course of combined oral prednisolone and fluticasone-propionate nasal spray is effective in decreasing polyp size and improving nasal symptoms for nasal polyposis, without sustained adverse effects.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1548    
    Comments [Add]    
    Cited by others 1    

Recommend this journal