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ORIGINAL ARTICLE
Year : 2016  |  Volume : 30  |  Issue : 3  |  Page : 141-145

The effect of the antioxidant drug "U-74389G" on amylase during ischemia reperfusion injury in rats


1 Department of Obstetrics and Gynecology, Mesologi County Hospital, Etoloakarnania, Greece
2 Department of Obstetrics and Gynecology, Aretaeio Hospital, Athens University, Attiki, Greece
3 Department of Surgery, Ippokrateio General Hospital, Athens University, Attiki, Greece
4 Department of Biologic Chemistry, Athens University, Medical School, Attiki, Greece
5 Exprerimental Research Center, ELPEN Pharmaceuticals, Co. Inc S.A., Pikermi, Attiki, Greece

Correspondence Address:
Tsompos Constantinos
Department of Obstetrics and Gynecology, Mesologi County Hospital, Nafpaktou Street, Mesologi 30200, Etoloakarnania
Greece
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4958.191177

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Background: This experimental study examined the effect of the antioxidant drug "U-74389G" on a rat model and particularly in an ischemia-reperfusion protocol. Settings and Design: The beneficial effect or noneffectiveness of that molecule was studied biochemically using blood mean amylase (A) levels. Materials and Methods: Forty rats of mean weight 231.875 g were used in the study. The levels were measured at 60 min of reperfusion (Groups A and C) and at 120 min of reperfusion (Groups B and D) with the administration of the drug U-74389G in Groups C and D. Results: U-74389G administration significantly decreased the predicted A levels by 8.40 ± 2.02% (P = 0.0001). Reperfusion time kept nonsignificantly increased the predicted A levels by 1.68 ± 2.44% (P = 0.4103). However, U-74389G administration and reperfusion time together produced a significant combined effect in keeping decreased the predicted A levels by 4.67 ± 1.26% (P = 0.0005). Conclusions: U-74389G administration whether it interacted or not with reperfusion time has a significant decreasing beneficial restoring short-term effect on amylase levels.


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