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ORIGINAL ARTICLE
Year : 2016  |  Volume : 30  |  Issue : 3  |  Page : 172-175

Correlation between prostate specific antigen levels and various prostatic pathologies


Department of Pathology, Dr. D.Y Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India

Correspondence Address:
Banyameen Mohamad Iqbal
Department of Pathology, Dr. D.Y Patil Medical College, Hospital and Research Centre, Pimpri, Pune - 411 018, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-4958.191184

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Background: Prostate-specific antigen (PSA) is a protein produced by the cells of the prostate gland. It is generally increased in diseases such as prostatitis, hyperplasia, and malignancy, but the correlation between various pathologies affecting the prostate gland and their corresponding rise in PSA values is not constant, and exceptions may occur. Aims and Objective: The aim of this study was to find out the spectrum and distribution of various prostatic lesions affecting men, with respect to their age and to find out the correlation between serum total PSA and histological findings. Materials and Methods: This study included a total of eighty samples (both transurethral resection of the prostate and prostatic biopsies) received in the histopathology laboratory, in our tertiary care center over a period of 1 year. All representative tissue sections were taken, and paraffin embedded blocks were made, which were finally sliced in a standard 0.3 mm microtome and stained with hematoxylin and eosin stain. They were finally examined under light microscopy for final evaluation and diagnosis. PSA levels were recorded in all the patients before surgical procedure was undertaken. Statistical analysis was done using Graph Pad in Stat 3 software. Analytical tests done included calculated probability (P value), Chi-squared test, tables containing data distribution in various formats and arithmetic mean. Results: About 51% of subjects studied were in the age group of 61-70 years. Maximum no of subjects had PSA ranging from 0 to 7 ng/ml (37.5%). Benign prostatic hyperplasia was the predominant lesion (38.75%) in the population studied. Chi-Squared distribution yielded a value of 11.49 while P < 0.01 indicating that there exists a positive correlation between the increasing PSA levels and chances of adenocarcinoma, the findings were statistically significant. Conclusion: We were able to determine the spectrum of prostatic lesions in different age groups, and the results indicate that the chances of finding malignancy with increasing values of PSA are more, but not a rule. It can only give a clue to the histopathologist to examine the sections more thoroughly.


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