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Year : 2017  |  Volume : 31  |  Issue : 3  |  Page : 158-161

Comparison of the risk of smoking on proprotein convertase subtilisin/kexin level in the plasma membrane of human sperm

1 Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh Province, Indonesia
2 Biochemistry Laboratory, Chemistry Department, Universitas Brawijaya, Malang, Indonesia

Correspondence Address:
D Dahril
Jalan Teuku Nyak Arief, Banda Aceh 23111, Aceh Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jms.jms_57_16

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Context: Smoking is an abhorrent habit mostly performed by some people in developing countries like Indonesia. Cigarette smoke is believed to cause respiratory disorders and diseases as well as problems of reproduction and infertility, especially for men. Previous research has studied about proprotein convertase subtilisin/kexin type 4 (PCSK4) that plays a role in the reproduction system. Aims: The present study is aimed at investigating the correlation between cigarette and disorder in PCSK4 molecule in the human sperm during fertilization process. Settings and Design: The study was conducted in Indonesia, one of developing countries where the number of smokers keeps increasing. The prospective study employs cross-sectional approach to compare the PCSK4 level in the spermatozoa of male smokers and nonsmokers. Materials and Methods: Spermatozoa ejaculation from ten individuals from both groups at productive age is collected. The enzyme-linked immunosorbent assay (ELISA) is carried out to compare the PCSK4 activity in both sample data. Statistical Analysis Used: The Shapiro–Wilk Method is employed to analyze the data distribution. Moreover, t-test is also used to investigate equality of means. Results: The finding indicates that based on ELISA, the PCSK4 level of male smokers is lower than that of nonsmokers. Conclusions: It is concluded that smoking can decrease the PCSK4 activities in sperm which eventually influence the fertilization process.

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