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Year : 2017  |  Volume : 31  |  Issue : 3  |  Page : 178-184

Serum testosterone and insulin resistance in type 2 male diabetics attending University of Calabar teaching hospital, Nigeria

1 Department of Chemical Pathology, Federal Medical Centre, Makurdi, Nigeria
2 Department of Medical Laboratory Science, Chemical Pathology Unit, University of Calabar, Calabar, Nigeria

Correspondence Address:
Ayu Agbecha
Department of Chemical Pathology, Federal Medical Centre, Makurdi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jms.jms_84_16

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Background of Study: Besides reproductive and sexual function, testosterone is reported to regulate metabolism, cardiovascular health, body composition, and enhancement cognitive function. Objective: The aim is to determine the impact of type 2 diabetes mellitus (T2DM) on serum testosterone, in a relationship with insulin resistance in men. Materials and Methods: This was a case-control study comprised 63 male type 2 diabetics (T2Ds) and sixty anthropometrically matched nondiabetic controls that fulfilled the inclusion criteria. Type 2 diabetes was diagnosed based on history and the WHO criteria. Results: There was a significantly lowered testosterone (P = 1 × 10-13) in the diabetics compared to the matched controls. A significantly elevated (P < 0.0005) fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and (P = 0.015) homeostatic model assessment of insulin resistance (HOMA IR) was observed in the diabetics compared with the matched controls. A significantly elevated (P = 0.001) testosterone and lowered (P = 0.009) HOMA-IR was observed in diabetics with good glycemic control compared to poor glycemic control. There was a significant (P < 0.05) inverse correlation (r = –0.421) between testosterone and connecting peptide (C peptide), testosterone and HOMA IR (r = –0.396), testosterone and HbA1c (r = –0.402), testosterone and FPG (r = –0.270) in male T2Ds. Conclusions: In this study, the low testosterone observed is a consequence of T2DM. Testosterone production seems to be impaired by elevated insulin that accompanies insulin resistance. Normalization of testosterone in controlled diabetes points at diabetic control instead of testosterone replacement therapy in the management of hypogonadism in male T2Ds.

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