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ORIGINAL ARTICLE
Year : 2019  |  Volume : 33  |  Issue : 2  |  Page : 71-75

Study of evolving trends in the clinicopathological profile of breast cancer patients attending a tertiary cancer center


Department of Radiotherapy, Regional Institute of Medical Sciences, Lamphelpat, Imphal, Manipur, India

Correspondence Address:
Deep Sikha Das
Department of Radiotherapy, Regional Institute of Medical Sciences, Lamphelpat, Imphal - 795 004, Manipur
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jms.jms_82_18

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Background: Breast cancer is by far the most frequent cancer in the women of Northeast India, with the possibility of 1 in 83 females developing breast cancer in their lifetime. Manipur presents a similar picture with breast cancer comprising 15.3% of female cancers. With westernization of lifestyle, there has been an increase in the prevalence of risk factors. The present study tries to evaluate the changing trends in the demographic, clinical, and pathological profile of the breast cancer patients presenting to a tertiary cancer center in Northeast India within a time frame of 10 years' gap. Materials and Methods: In this descriptive, retrospective study, the records of histologically confirmed cases of breast cancer managed at the institute a decade apart were analyzed with respect to the various risk factors, stage, histological features, and receptor status. Changes in the trends were recorded. Results: The mean age at presentation was found to be younger in 2015–2017 compared to 2002–2004 (P < 0.05). More premenopausal women were diagnosed with breast cancer in 2015–2017 as compared to 2002–2004 (P < 0.005). When age at first childbirth was compared, there was significantly advanced age in 2015–2017. Body mass index was significantly higher in 2015–2017 group. When change in receptor status was evaluated, there was a decrease in cases of estrogen receptor/progesterone receptor positivity and increase in triple-negative cases in 2015–2017, which was statistically significant (P < 0.05). Conclusion: Within an interval of a decade, there has been a significant change in the clinicopathological profile of the breast cancer patients presenting to the institute. More aggressive patterns of disease have become more common with early age of presentation and aggressive biological behavior of receptor-negative tumors. Thus, we need to have a relook at the strategy to manage breast cancer in the coming future.


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