Print this page Email this page
Users Online: 80
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 34  |  Issue : 1  |  Page : 41-46

Clinicopathological and immunohistochemical study of male breast carcinoma: Experience from a tertiary care teaching hospital of South India


Department of Pathology, Employees' State Insurance Corporation Medical College and PGIMSR, Bengaluru, Karnataka, India

Correspondence Address:
Panduranga Chikkannaiah
Department of Pathology, Employees' State Insurance Corporation Medical College and PGIMSR, Bengaluru - 560 010, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jms.jms_75_20

Rights and Permissions

Introduction: Male breast carcinoma (MBC) accounts for 1% of all breast carcinomas. Compare to female counter part, they present with advance stage and high lymph node positivity and carries a poor prognosis. Invasive ductal carcinoma (IDC) no special type was the most common histopathological type. They express high hormonal receptor positivity. Few epidemiological studies of MBC are available in the northern part of India, but studies in the Southern India are spares. Hence, this study was undertaken to document the clinicopathological parameters and IHC profile associated with MBC in this region of India. Materials and Methods: This is a retrospective study for a period of 10 years. Each case was assessed for clinical presentation, laterality, quadrant of the breast involved, fine-needle aspiration cytology diagnosis, mammography, type of surgery, size of tumor, histopathological diagnosis, lymph node status, metastasis, SBR grading, and TNM staging. Immunohistochemical expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 (Her 2) Neu, and Ki 67 was graded as per the standard protocol. Results: During the study period, 16 MBC were observed, constituting 1.5%. The median age is 59 years; painless lump is the most common presentation. IDC no special type is the most common variant. The left breast was commonly affected (81.25%). None of them had a family history of breast carcinoma; central subareola region is the most common anatomical site involved. 62.5% were in Grade 2 and 28.5% showed ipsilateral axillary lymph node involvement. High hormonal receptor positivity was noted in 100% cases, whereas 12.5% showed Her 2 amplifications. Conclusion: Our study also conclude that the pathology of MBC is as most of the cases are presenting with Stage 2 and less lymph node involvement which may carry a better prognosis; however, more studies on the large sample are required to document the same.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed98    
    Printed0    
    Emailed0    
    PDF Downloaded7    
    Comments [Add]    

Recommend this journal