| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 36
| Issue : 3 | Page : 94-100 |
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Elevated circulating levels of matrix metalloproteinase-9 and its association with cardiovascular risk in young smokers
Dinesh Nath, Meera Shivasekar, VM Vinodhini
Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulthur, Tamil Nadu, India
Correspondence Address:
Dr. Meera Shivasekar
Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulthur - 603 203, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jms.jms_98_21
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Background: Smoking causes cardiovascular risk which may alter the stability between the production and degradation of the extracellular matrix. Matrix metalloproteinase-9 (MMP-9) is a zinc-containing endopeptidase that degrades extracellular matrix and plays a vital role in tissue remodeling. As a result, elevated serum MMP-9 levels produced by smoking, particularly in younger age, raise the risk of future coronary heart disease (CHD).
Aim and Objective: Our aim is to find out the possible relationship between circulating MMP-9 and the risk of cardiovascular disease in young smokers.
Materials and Methods: The study contains three groups. Group 1 includes 60 young active smokers with diabetic CHD, Group 2 includes 60 young active smokers with CHD, and Group 3 includes 60 healthy controls as nonsmokers who were attending SRM Medical College Hospital in Tamil Nadu for cardiology and medicine OP. Enzyme-linked immune sorbent assay was used to measure serum MMP-9, high-sensitivity C-reactive protein (hsCRP), and apolipoprotein E (APO-E) levels, and enzymatic techniques were employed to quantify lipid levels.
Results: When compared to the controls, the mean serum MMP-9, hsCRP, and APO-E levels were significantly higher in both the groups. The study also shows a significant positive association between MMP-9 with hsCRP, APO-E, smoking burden, and smoking intensity.
Conclusion: The study concludes that increased MMP-9 levels, particularly in inflammatory conditions caused by smoking, are associated with an increased risk of future cardiovascular disease.
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