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Year : 2022  |  Volume : 36  |  Issue : 3  |  Page : 94-100

Elevated circulating levels of matrix metalloproteinase-9 and its association with cardiovascular risk in young smokers

Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulthur, Tamil Nadu, India

Correspondence Address:
Dr. Meera Shivasekar
Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulthur - 603 203, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jms.jms_98_21

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Background: Smoking causes cardiovascular risk which may alter the stability between the production and degradation of the extracellular matrix. Matrix metalloproteinase-9 (MMP-9) is a zinc-containing endopeptidase that degrades extracellular matrix and plays a vital role in tissue remodeling. As a result, elevated serum MMP-9 levels produced by smoking, particularly in younger age, raise the risk of future coronary heart disease (CHD). Aim and Objective: Our aim is to find out the possible relationship between circulating MMP-9 and the risk of cardiovascular disease in young smokers. Materials and Methods: The study contains three groups. Group 1 includes 60 young active smokers with diabetic CHD, Group 2 includes 60 young active smokers with CHD, and Group 3 includes 60 healthy controls as nonsmokers who were attending SRM Medical College Hospital in Tamil Nadu for cardiology and medicine OP. Enzyme-linked immune sorbent assay was used to measure serum MMP-9, high-sensitivity C-reactive protein (hsCRP), and apolipoprotein E (APO-E) levels, and enzymatic techniques were employed to quantify lipid levels. Results: When compared to the controls, the mean serum MMP-9, hsCRP, and APO-E levels were significantly higher in both the groups. The study also shows a significant positive association between MMP-9 with hsCRP, APO-E, smoking burden, and smoking intensity. Conclusion: The study concludes that increased MMP-9 levels, particularly in inflammatory conditions caused by smoking, are associated with an increased risk of future cardiovascular disease.

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