Journal of Medical Society

BRIEF REPORT
Year
: 2012  |  Volume : 26  |  Issue : 3  |  Page : 154--155

Non-structural protein 1 antigen capture kit as an early dengue diagnostic tool


Sheevani Sheemar, Gomty Mahajan, Shashi Chopra, Jaspal Kaur 
 Department of Microbiology, Punjab Institute of Medical Sciences, Jalandhar, India

Correspondence Address:
Sheevani Sheemar
144, Gurjeet Nagar, Garha Road, Jalandhar
India

Introduction: Dengue is a major public health problem in tropical and sub-tropical regions of the world. Detection of specific Immunoglobulin M [IgM] antibodies forms the mainstay for diagnosis of dengue infection. However, IgM antibodies develop after 4-5 days of infection and there is an urgent need for an alternative diagnostic tool that can detect dengue infection during this phase. Materials and Methods: We carried out a prospective study with the aim to analyze the utility of a commercial non-structural protein 1 antigen (NS1 Ag) based rapid immunochromatographic test for detection of dengue infection in anti-dengue IgM seronegative serum samples. Results: A total of randomly selected 86 IgM negative samples were tested for the presence of dengue NS1 Ag. Of these, 59.30% (51/86) were positive for NS1 Ag. Conclusions: Our findings, therefore, supplement the findings of other similar studies suggesting NS1 Ag as an early diagnostic marker that is feasible to look for in a routine diagnostic laboratory. Furthermore, NS1 Ag assay may be a useful tool for detecting dengue infection during acute phase of infection when IgM antibodies are not formed to the detectable levels.


How to cite this article:
Sheemar S, Mahajan G, Chopra S, Kaur J. Non-structural protein 1 antigen capture kit as an early dengue diagnostic tool.J Med Soc 2012;26:154-155


How to cite this URL:
Sheemar S, Mahajan G, Chopra S, Kaur J. Non-structural protein 1 antigen capture kit as an early dengue diagnostic tool. J Med Soc [serial online] 2012 [cited 2021 Feb 26 ];26:154-155
Available from: https://www.jmedsoc.org/article.asp?issn=0972-4958;year=2012;volume=26;issue=3;spage=154;epage=155;aulast=Sheemar;type=0