Journal of Medical Society

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 28  |  Issue : 3  |  Page : 180--184

Clinicopathological correlation in primary nephrotic syndrome


Ghanachandra K Singh1, Sharatkumar N Singh2, Dwarika Niroula2, lboton Y Singh2, Kaushik Debnath3, Romesh L Sharma2 
1 Department of Medicine, Jawaharlal Nehru Institute of Medical Sciences Hospital, International School and Junior College, Regional Institute of Medical Sciences, Imphal, Manipur, India
2 Department of Medicine, International School and Junior College, Regional Institute of Medical Sciences, Imphal, Manipur, India
3 Department of 2Pathology, International School and Junior College, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Ghanachandra K Singh
Department of Medicine Jawaharlal Nehru Institute of Medical Sciences Hospital, Porompat, Imphal - 795 001, Manipur
India

Objective: To study the clinicopathological correlation in patients suffering from primary/idiopathic nephrotic syndrome. Materials and Methods: A total of 34 cases of idiopathic nephrotic syndrome were included in the present study. All patients had undergone renals biopsy for histological diagnosis. Results: The patients were subjected to renal biopsy and on the basis of light microscopic findings they were divided into two broad groups. Group A included 25 patients whose renal biopsy showed histological picture of minimal change disease. Group B included nine patients whose renal biopsy showed features other than those seen in minimal change disease. Most patients presented in the 2 nd and 3 rd decade (range was found from 14 to 80 years). Increased serum creatinine (<1.6 mg%) wasfound in two (8%) in group A and four (44%) in group B. Thus, the number of patients having high serum creatinine was significantly higher in group B. Nine patients (33%) in group A and three (33%) in group B had low glomerular filtration rate (GFR;i.e.,<90m1/min). Low serum protein (i.e.,<6 g%) was seen in 18(72%) in group A and five (55.5%) in group B and low serum albumin (i.e.,< 3.2 g%) was found in 21 (84%) in group A and six (66%) in group B. The mean serum cholesterol was 426.76 ΁ 77.11 mg% and mean triglyceride was 269.80 ΁ 148.11 mg% in group A, while in group B the mean cholesterol was 357.33 ΁ 116.19 mg% and mean serum triglyceride was 231.55 ΁ 73.85 mg%. Conclusion: Most patients of nephrotic syndrome presented in the 2 nd and 3 rd decades. All patients in both the groups had high serum triglycerides. Seventy-three percent of nephrotic syndrome cases had histopathological diagnosis of minimal change disease, 8.8% had membranoproliferative glomerulonephritis. Membranous glomerulonephritis, focal segmented glomerulosclerosis, and diffuse proliferative glomerulonephritis accounted for 6% cases each.


How to cite this article:
Singh GK, Singh SN, Niroula D, Singh lY, Debnath K, Sharma RL. Clinicopathological correlation in primary nephrotic syndrome.J Med Soc 2014;28:180-184


How to cite this URL:
Singh GK, Singh SN, Niroula D, Singh lY, Debnath K, Sharma RL. Clinicopathological correlation in primary nephrotic syndrome. J Med Soc [serial online] 2014 [cited 2021 May 6 ];28:180-184
Available from: https://www.jmedsoc.org/article.asp?issn=0972-4958;year=2014;volume=28;issue=3;spage=180;epage=184;aulast=Singh;type=0